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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Science Teams Against Disease ： ウィキペディア英語版 Science Teams Against Disease Science Teams Against Disease or (STAD-Schizophrenia ) is a fund under (The Community Foundation ) based in the state of Virginia, USA. It aims to attract philanthropic support from all over the world to enable a team of researchers from across the US to discover new treatments for Schizophrenia. This project is based on the discovery that two of the target receptors for antipsychotic drugs come together to form a complex with unique signaling properties. ==Research== In 2008, a Nature paper by Gonzalez-Maeso and colleagues (Icahn School of Medicine at Mount Sinai) reported that two G protein-coupled receptors (GPCRs) that are targeted by antipsychotic drugs, the serotonin 5-HT2AR and the glutamate mGlu2R receptors, come together to form a complex that is deregulated in schizophrenic patients.〔http://www.ncbi.nlm.nih.gov/pubmed/18297054〕 The functional consequences of this interaction were revealed in the 2011 Cell paper from Logothetis lab (Virginia Commonwealth University) in which this heteromeric complex was shown to be a convergent site for the activity of anti- or propsychotic drugs.〔http://www.ncbi.nlm.nih.gov/pubmed/22118459〕 According to the authors, atypical antipsychotics work through this receptor complex (5-HT2AR/ mGlu2R) and signal quite differently through the complex compared to how they signal through one or the other receptor alone.〔http://www.ncbi.nlm.nih.gov/pubmed/22118459〕 The signaling through the receptor complex could predict whether a drug would act as an antipsychotic or a pro-psychotic (e.g. the hallucinogen drug LSD).〔http://www.ncbi.nlm.nih.gov/pubmed/22118459〕 This work has opened the possibility of utilizing signaling to screen for new drugs that will target this receptor complex specifically and not cross react with dopamine receptors, which can give rise to unwanted side effects. The study also discovered that combinations of drugs simultaneously targeting each of the two receptors in the complex could be effective in animal models in cases when drugs targeting one or the other receptor alone were ineffective.〔http://www.ncbi.nlm.nih.gov/pubmed/22118459〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Science Teams Against Disease」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.